That’s actually a fair point. As far as I know, there’s no reliable way to predict long-term side effects without studying it for a long time.
I've seen Dr. Kruse speculate that the mechanism could inadvertently block deuterium depletion, which could contribute to cognitive issues down the line.
"GLP-1 agonists significantly slow gastric emptying and alter the secretion profile of the pancreas.
Deuterium Retention: By slowing the "exhaust" flow, these drugs may inadvertently trap deuterium and metabolic waste in the upper GI tract.
The Cognitive Price: While they may help with weight loss (by altering the leptin-AMPK loop), they achieve it at the cost of long-term cognitive "shrinkage" because the Vagus nerve cannot relay a "clean" metabolic signal to the brain."
"GLP-1 agonists significantly slow gastric emptying and alter the secretion profile of the pancreas.
Deuterium Retention: By slowing the "exhaust" flow, these drugs may inadvertently trap deuterium and metabolic waste in the upper GI tract.
The Cognitive Price: While they may help with weight loss (by altering the leptin-AMPK loop), they achieve it at the cost of long-term cognitive "shrinkage" because the Vagus nerve cannot relay a "clean" metabolic signal to the brain."
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