jSA
· 1w
Sure, but then one would expect the symptoms to be heterogeneous within different demographics, and not, for example, all the gays from the 1980s to all get Karposi sacoma.
What symptoms? You mean the OIs? Why would you? Many are caused by environmental organisms that most people's immune systems keep under control, e.g. everyone is exposed to pneumocystis at various points in their life.
And actually the presentation usually does vary, not everyone gets Kaposi's, not everyone gets cryptococcal meningitis, for example. Within the same demographic, seroprevalence of CMV isn't 100%, so only some will have reactivation in advanced HIV.
Also you can actually predict which OIs are possible depending on CD4 count, e.g. you only get disseminated MAC at very low counts.